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Since their initial description in 19481, small DNA fragments travelling in the non-cellular component of internal bodily fluids and excretions have revolutionized numerous fields in public health and preventive medicine2,3,4,5,6. Although its origins have been a topic of controversy, cell-free DNA (cfDNA) is generally thought to arise from cellular breakdown mechanisms but also through active...
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transcriptome alterations
Karen Gambaro, Maud Marques, Suzan McNamara, Mathilde Couetoux du Tertre, Zuanel Diaz, Cyrla Hoffert, Archana Srivastava, Steven Hébert, Benoit Samson, Bernard Lespérance, Yoo-Joung Ko, Richard Dalfen, Eve St- Hilaire, Lucas Sideris, Felix Couture, Ronald Burkes, Mohammed Harb, Errol Camlioglu, Adrian Gologan, Vincent Pelsser, André Constantin, Celia M.T. Greenwood, Sabine Tejpar, Petr Kavan, Claudia L. Kleinman,...
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Exactis Innovation is a pan-Canadian research network that accelerates biomarker-led clinical and translational research in areas of high-unmet medical need. Precision Medicine in Cancer Care The past decade has seen the emergence of precision medicine, a complicated method of cancer treatment in which different molecular variants found in tumours guide oncologists to the use of...
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Study of lasofoxifene versus fulvestrant in patients with metastatic breast cancer will include seven precision-medicine Exactis Network study locations COLUMBUS, Ohio (September 29, 2020) — Sermonix Pharmaceuticals Inc., a privately held biopharmaceutical company focused on the development of female oncology products in the precision medicine metastatic breast cancer arena, today announced a collaboration with Exactis...
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Exactis Innocation, cell‑free, DNA
Miguel Alcaide, Matthew Cheung, Jack Hillman, S. Rod Rassekh, Rebecca J. Deyell, Gerald Batist, Aly Karsan, AlexanderW. Wyatt, Nathalie Johnson, DavidW. Scott7 & Ryan D. Morin1* Abstract Cell-free DNA (cfDNA) has become a comprehensive biomarker in the fields of non-invasive cancer detection and monitoring, organ transplantation, prenatal genetic testing and pathogen detection. While cfDNA samples can...
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Exactis is pleased to be working with Dr. Jonathan Spicer on a phase I interventional pilot open-label trial, using rhDNase1 as a treatment for COVID-19 positive patients. The objectives are to assess the safety and feasibility of inhaled rhDNase1 in severely ill COVID-19 patients requiring admission, to evaluate the impact of rhDNase1 in limiting progression...
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The Exactis-01 trial, a PMT sub-study “Multi-centre Observational Study to Evaluate the Clinical Utility of Returning Genomic Aberration Results Using the Oncomine Precision Assay (OPA) in Advanced or Metastatic NSCLC within the Exactis Network” will be open at several PMT sites and Princess Margaret Hospital, the PI of the study is Dr. Jason Agulnik from...
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The Exactis-03 trial “A  Phase I/II Basket Trial of the Combination of PARP inhibitor and Navitoclax in  Women with High Grade Serous Epithelial Ovarian Cancer and Triple Negative Breast Cancer” led by Dr. Helen MacKay from Sunnybrook Hospital, will be opened across PMT Network sites and Princess Margaret Hospital. Phase I will define the dose and schedule of navitoclax that can be combined safely...
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Sermonix Pharmaceuticals’ study “Evaluation of Lasofoxifene Versus Fulvestrant in Advanced or Metastatic ER+/HER2− Breast Cancer With an ESR1 Mutation.” The clinical trial is ongoing in the United States, and Exactis is currently performing a feasibility assessment across Canada to identify sites interested in participating in the study, if interested please contact dsalazar@exactis.ca.  https://clinicaltrials.gov/ct2/show/NCT03781063?term=sermonix&draw=2&rank=1
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