PUBLICATIONS

Exactis’ presented our PMT Databank at the 2023 CADTH Symposium in Ottawa in May 2023. Our pan-Canadian network of hospital sites across the country, helped us enroll patients and collect longitudinal real-world data (RWD) in a standardized secured de-identified online database. To date, we have close to 9,000 cancer participants.

Exactis’ PMT registry offers invaluable insights into disease impacts, disparities, and treatment patterns. PMT, a standardized digital cancer registry, spans 16 hospitals across 5 Canadian provinces. This comprehensive data, inclusive of demographics, diagnosis, treatments, and biomarkers, underscores the registry’s potential to enhance our understanding of oncological trends in Canada, ensuring more accurate evaluations of clinical benefits and treatment gaps in the real-world setting.

Exactis presented this multi-center observational study that aims to assess the Oncomine Precision Assay (OPA) against the standard of care in detecting genomic aberrations in NSCLC patients. The primary objective focuses on the detection rate of specific genomic aberrations, while the secondary examines the clinical utility of OPA results in guiding treatment decisions. Initiated in May 2021, this study enrolled 100 participants across six Canadian sites.

This study delved into the genomic adaptability of metastatic lesions in response to first-line systemic therapy by analyzing longitudinal liver metastatic samples for copy number aberration (CNA) and its transcriptomic effects. Notably, a majority of CNA regions linked with PFS were exclusive to metastatic lesions, emphasizing the criticality of examining metastases in clinical contexts.