PUBLICATIONS
A network approach to developing immuno-oncology combinations in Canada
The molecular cancer registry Personalize My Treatment, managed by the Networks of Centres of Excellence nonprofit organization Exactis Innovation, is uniquely positioned to accelerate Canadian immuno-oncology (IO) research efforts throughout its national network of cancer sites.
Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial
Precision medicine focuses on DNA abnormalities, but not all tumors have tractable genomic alterations. Our study shows that genomic and transcriptomic profiling are both useful for improving therapy recommendations and patient outcome, and expand personalized cancer treatment.
Targeted error-suppressed quantification of circulating tumor DNA using semi-degenerate barcoded adapters and biotinylated baits
Ultrasensitive methods for rare allele detection are critical to leverage the full potential offered by liquid biopsies. Here, we describe a novel molecular barcoding method for the precise detection and quantification of circulating tumor DNA (ctDNA).
Biopsies: next-generation biospecimens for tailoring therapy
In this review, we describe the existing procedures for sample procurement and processing of next-generation biospecimens, and highlight the issues involved in this endeavour, including the ethical, logistical, scientific, informational, and financial challenges accompanying next-generation biobanking.